From an article published in the ‘Royal Society of Medicine Press’:

Achilles tendinopathy: aetiology and management : this Article discusses more on detailing the issues with Cipro and related drugs with tendon pain and rupturing here is a Quote and the link:

"The aetiology of tendinopathy remains uncertain and many factors have been implicated,1 including free radical damage occurring on reperfusion after ischaemia, hypoxia, hyperthermia and impaired tenocyte apoptosis.16 In animals, tendinopathy can be induced by local administra-tion of cytokines and prostaglandins.17 luoroquinolones have also been implicated: ciprofloxacin enhances inter-

leukin-1b mediated release of matrix metalloproteinase (enzymes that break down proteins) (MMP3) release, inhibits tenocyte proliferation and reduces collagen and matrix synthesis.18 Changes in the expression of genes regulating cell–cell and cell–matrix interactions have been reported, with down-regulation of MMP3 mRNA in tendinopathic Achilles tendon samples.19 Type I and type III collagen mRNAs have been found at higher levels in tendinopathic samples than in normal samples.19 In

tendinopathic Achilles tendons, upregulation of MMP2 and vascular endothelial growth factor has been described, whilst MMP3 was downregulated.20 Imbalance in MMP

activity in response to repeated injury or mechanical strain may result in tendon degeneration."

For full article click here: http://jrsm.rsmjournals.com/cgi/reprint/97/10/472

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